Cryolys cooling option - Bertin Instruments


Cryolys cooling option

The Cryolys is a patented cooling option, compatible with Precellys tissue homogenizers, that keeps the temperature of the samples between 0°C and 10°C during homogenization.

The Cryolys is the cooling option Precellys24. Its patented technology used with dry ice or liquid nitrogen cools all samples before, during and after the homogenization process.

It allows for extraction of stable RNA and native-state proteins. The three possible flowrates are adapted to all needs and the thermometer probe enables precise temperature monitoring.

Cryolys is the best solution to protect sensitive molecules from heat degradation during homogenization. It is ideal for working on thermo-sensitive molecules: RNA, siRNA, metabolites, enzymes and proteins.

Cryolys video

Cold air is sprayed around the tubes for cooling samples during homogenization with the patented Cryolys cooling option, keeping temperature-sensitive molecules in a native state.

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Cryolys cooling option

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  • 24lb / 11 kg


  • Length 408 mm x Width 278 mm x Height 311 mm


  • CE, FCC part 15 and 18 certified

Compressed air (lab network or canister):

  • Needed

Power requirement:

  • 100-230 VAC / 50-60 Hz / Power 2A


  • less than 70 dB

Catalogue number:

  • P000671-CLYS0-A

Air flow rate settings:

  • 80-90-110 L/min


  • from 5 bars ( 73 PSI) to 10 bars (145 PSI)

Flow rate:

  • up to 110L/min (6.6m3/h)

Consumption (run time):

  • 2L of liquid nitrogen for 5 min or 1 kg of dry ice for 1.5h

Clean and dry:

  • Purity 99.99%, water less than 5ppm

Efficient cooling for efficient extraction Cryolys is the only patented cooling unit to protect thermo-sensitive molecules during homogenization with Precellys homogenizers. It restricts the heat generation of each sample and maintains their temperature around 10°C. Cryolys delivers higher yield and quality extraction. Easy-handling Thanks to the thermometer probe included with the Cryolys, precise temperature monitoring is possible before, during and after homogenization. The thermo-protection Cryolys unit enables the extraction of stable RNA and native-state proteins. Cold air, -50°C, is sprayed around each tube in order to keep them at a stable temperature of approximately 10°C during homogenization.

The Cryolys is the cooling option for Precellys24 and prevents the degradation of thermo-sensitive molecules like RNA or proteins. Its patented technology maintains a low temperature (0°C- 10°C) before, during and after the grinding process with Precellys. Cryolys technology is based on the use of a compressed air source as a cooling medium. An external compressed air source is linked to the Cryolys which is linked to the Precellys’ lid. The compressed air passes through the internal tank of Cryolys containing either dry ice or liquid nitrogen. The cooled air is then spread inside the Precellys’ lid directly to the tubes. With the appropriate airflow rate, the temperature inside the Precellys’ lid can reach 0°C in 5 minutes and protect thermo-sensitive molecules from degradation

Abstracts of some application notes related to Cryolys.

  • To access all application notes and full versions, visit the Application Center.Enzyme assay from frozen abdominal krill tissue, Antarctic Krill Group, Dept. Polar Biological Oceanography Alfred Wegener Institute for Polar and Marine Research in the Helmholtz, Association, Am Handelshafen , Bremerhaven, Germany, Animal & Aquaculture science (code: 03712-810-DU063)
  • Binding of one lipophilic compound to the Precellys tubes with ceramic beads during tissue homogenization, Songmao Zheng, Justina C. Calamia, Departments of Pharmaceutics, University of Washington, Seattle, WA, USA, Pharmaceutical sciences (code:03712-810-DU067)
  • Metabolomic study of the red algae Chondrus crispus, MetaboMER, Metabolomic Platform, FR2424 CNRSUPMC, Station Biologique de Roscoff, Roscoff, France, Animal & Aquaculture science (code: 03712-810-DU068)
  • MicroRNA expression profiling of individual rat hypothalamic nuclei, Neuroendocrinologie Moléculaire de la Prise Alimentaire, University of Paris-Sud 11, UMR 8195, Orsay, France and Neuroendocrinologie Moléculaire de la Prise Alimentaire, CNRS, Centre de Neurosciences, Paris-Sud UMR8195, Orsay, France, Biomedical & Health sciences (code: 03712-810-DU074)
  • Sample extraction for quantification of mold antigen, Institut für Prävention und Arbeitsmedizin, Institut der Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp Platz, Bochum, Germany, Biomedical & Health sciences (code: 03712-810-DU075)

Register for the Application Center and access more than 1000 scientific references.

Reasons to choose Cryolys cooling option

Full application support composed of more than 2,000 scientific documents based on user experiences to determine the best protocol for your samples.

Support is provided online 24/7 by our Application Center, or by our dedicated Application Specialists

With 30 different lysing kits available, Precellys is the most versatile range of homogenizers.

It allows users to homogenize, grind or lyse all sample types.

The easy-handling features allow the Precellys to be used without advanced training

10 years of expertise in sample preparation and more than 30,000 scientists who use the Precellys worldwide

A worldwide distribution network to support you wherever you are

Expert advice

Sophie Dubacq

Application and Product Specialist

"Need to quickly reduce the temperature inside the Precellys? Use liquid nitrogen (5min cool-down). If you are not in a rush, use dry ice: you will have more than 30 minutes of autonomy."



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