Cryolys cooling option - Bertin Instruments

    Cryolys cooling option keeps temperature of the samples between 0°C and 10°C during homogenization to preserve sensitive molecules

    Cryolys cooling option

    The Cryolys is a patented cooling option, compatible with Precellys homogenizers, that keeps temperature of the samples between 0°C and 10°C during homogenization.

    The Cryolys is the cooling option for Precellys Evolution and Precellys24. Its patented technology used with dry ice or liquid nitrogen, cools down every samples before, during and after the homogenization process. It allows extraction of stable RNA and native-state proteins. The 3 possible flowrates are adapted to every needs and the thermometer probe permits a precise temperature monitoring.

    Cryolys is the best solution to protect the sensitive molecules from heat degradation during the homogenization. Cryolys is ideal while working on thermo-sensitive molecules: RNA, siRNA, metabolites, enzymes, proteins.

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    Cryolys cooling option


    Reasons to choose Cryolys cooling option

    Full application support gathering 2 000+ scientific documents based on user experiences to determine the best protocol for your samples.

    The support is available online 24/7 through our Application Center or with the support of our dedicated Application Specialists

    30 different lysing kits available, Precellys is the most versatil range of homogenizers.

    It allows to homogenize, grind or lyse any type of samples.

    The easy-handling features allow the Precellys to be used without any advanced training

    10 years of expertise in sample preparation and 30 000+ scientists using the Precellys worldwide

    A worldwide distribution network to support you anywhere you are

    Weight :

    • 24lb / 11 kg

    Dimensions :

    • Length 408 mm x Width 278 mm x Height 311 mm

    Norms :

    • CE, FCC part 15 and 18 certified

    Power requirement :

    • 100-230 VAC / 50-60 Hz / Power 2A

    Noise :

    • less than 70 dB

    Catalogue number :

    • EQ05068-200-RD000.0 (for Precellys24) / EQ05068-200-RD001.0 (for Precellys Evolution)

    Air flow rate settings :

    • 80-90-110 L/min

    Compressed air (lab network or canister) :

    • Needed

    Pressure :

    • from 5 bars ( 73 PSI) to 10 bars (145 PSI)

    Flow rate :

    • up to 110L/min (6.6m3/h)

    Consumption (run time) :

    • 2L of liquid nitrogen for 5 min or 1 kg of dry ice for 1.5h

    Clean and dry :

    • Purity 99.99%, water less than 5ppm

    Efficient cooling for efficient extraction Cryolys is the only patented cooling unit to protect thermo sensitive molecules during homogenization with Precellys homogenizers. It allows to restrict heat generation of each samples and maintain their temperature around 10°C. Cryolys allows to achieve higher yield and quality of extraction.

    Easy-handling Thanks to the thermometer probe included with the Cryolys a precise temperature monitoring is enabled before, during and after homogenization.

    Thermo-protection Cryolys unit enables the extraction of stable RNA and native-state proteins. Cold air, -50°C, is sprayed around each tube in order to keep a stable temperature of the tubes around 10°C during homogenization.

    The Cryolys is the cooling option for Precellys24 and Precellys Evolution to prevent any degradation of thermo-sensitive molecules like RNA or proteins. Its patented technology allows to maintain a low temperature (0°C- 10°C) before, during and after the grinding process with Precellys. The Cryolys technology is based on the use of compressed air source as cooling media. An external compressed air source is linked to the Cryolys which is link to the Precellys’ lid. The compressed air passes through the internal tank of Cryolys containing either dry ice or liquid nitrogen. The cooled air is then spread inside the Precellys’s lid directly to the tubes. With the appropriate airflow rate, the temperature inside the Precellys’ lid can reach 0°C in 5min and protect thermo-sensitive molecules from degradation

    Here are abstracts of some applications notes related to Cryolys.

    • To read all the application notes and the full versions, visit the Application Center.Enzyme assay from frozen abdominal krill tissue,
      Antarctic Krill Group, Dept. Polar Biological Oceanography Alfred Wegener Institute for Polar and Marine Research in the Helmholtz, Association, Am Handelshafen , Bremerhaven, Germany, Animal & Aquaculture science (code: 03712-810-DU063)
    • Binding of one lipophilic compound to the Precellys tubes with ceramic beads during tissue homogenization,
      Songmao Zheng, Justina C. Calamia, Departments of Pharmaceutics, University of Washington, Seattle, WA, USA, Pharmaceutical sciences (code:03712-810-DU067)
    • Metabolomic study of the red algae Chondrus crispus,
      MetaboMER, Metabolomic Platform, FR2424 CNRSUPMC, Station Biologique de Roscoff, Roscoff, France, Animal & Aquaculture science (code: 03712-810-DU068)
    • MicroRNA expression profiling of individual rat hypothalamic nuclei,
      Neuroendocrinologie Moléculaire de la Prise Alimentaire, University of Paris-Sud 11, UMR 8195, Orsay, France and Neuroendocrinologie Moléculaire de la Prise Alimentaire, CNRS, Centre de Neurosciences, Paris-Sud UMR8195, Orsay, France, Biomedical & Health sciences (code: 03712-810-DU074)
    • Sample extraction for quantification of mould antigen,
      Institut für Prävention und Arbeitsmedizin, Institut der Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp Platz, Bochum, Germany, Biomedical & Health sciences (code: 03712-810-DU075)


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    Cold air is sprayed beside the tubes for cooling samples during homogenization with patented Cryolys cooling option, keeping temperature sensitive molecules in native state.

    Watch the other Cryolys cooling option videos

    Expert advice

    Sophie Dubacq

    Application and Product Specialist

    "Need to quickly down the temperature inside the Precellys, then use liquid nitrogen (5min cool-down). If you are not in a rush, use dry ice, you will have more than 30min of autonomy."




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