Precellys Evolution homogenizer - Bertin Instruments


Precellys Evolution homogenizer

Precellys Evolution is the most advanced tissue homogenizer combining high efficiency and versatility for all sample preparation needs.

Prior to performing any analysis of molecules of interest, biological samples must first be prepared, which generally requires tissue homogenization. The Precellys® Evolution tissue homogenizer brings together performance, versatility and high-level efficiency enabling you to safely carry out all your routine and R&D projects.


Watch Precellys Evolution – the most efficient and flexible homogenizer – in action!

Genclis SAS is a CRO mainly working on food samples. The aim of this application is to extract proteins recognized by IgE antibodies from allergic patients. The challenge is to extract protein with the best possible quality. The Precellys Evolution tissue homogenizer extracts high quality proteins in large quantities from dry food samples. Moreover, the capacity to process 6 x 15mL tubes is a real advantage and saves time.

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Precellys Evolution homogenizer

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  • From 8 to 96 wells, 300µL
  • From 1 to 24 tubes, 2mL/0.5mL
  • From 1 to 12 tubes, 7mL
  • From 1 to 6 tubes, 15mL

Speed range:

  •  From 4,500 rpm to 10,000 rpm (increment by 100 rpm)

Locking system:

  • Automatic tubes locking system – patented


  • The software allows users to save an unlimited number of protocols

Number of cycles:

  • up to 10

Cycles time:

  • up to 90sec (increment by 1sec)


  • 60lb / 27kg


  • L: 378mm, W: 515mm, H: 400mm (632mm with open lid)

Power requirement:

  • 90 – 250VAC / 50-60 Hz Power: 1 kVA


  • Less than 70 dB


  • CE and CFR 47 part 15 certified

Catalogue number:

  • P000062-PEVO0-A


Download the user guide

Efficiency on every sample:

  • Up to 10,000 rpm to process and standardize any sample preparation in seconds. Even the hardest samples such as hair, teeth and bones can be fully ground in a short period of time.

Easy handling:

  • The innovative and patented automatic tube locking system allows for easy handling of the Precellys Evolution without advanced training

Best life time:

  • The high quality manufacturing of the Precellys Evolution drastically reduces the need for maintenance and additional expenditure over the years – The Precellys Evolution is made in France

Adapted to any type of sample:

  • The high flexibility of the Precellys Evolution, which is capable of handling four sizes of tube (0.5, 2, 7 and 15 mL), makes it the perfect tool when processing samples of different sizes, weight or volume.

Protection for thermo-sensitive molecules:

  • The Precellys Evolution is compatible with the Cryolys cooling unit. This combination allows users to protect sensitive molecules when processing samples.


Precellys technology presents two main features:

1- The 8-figure 3D-motion (multi-directional) movement of the tubes. The same high level of energy given to the beads inside each tube ensures equal homogenization efficiency for all processed samples (up to 24 at once). Thanks to this complex movement, the Precellys Evolution can disrupt any type of sample (even the hardest) in seconds with perfect reproducibility while limiting heat generation.
2- The patented locking vacuum system of the tubes during the process. The Press’n block system saves time and energy. It makes it easier to handle equipment and secures the tubes before the grinding process.

7mL holder pack

7mL holder pack

This optional tube holder allows the use of up to 12 x 7mL tubes in the Precellys Evolution. It contains one tube holder and one blocking plate.
Cat. No.: S000911-PEVO0-A

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15mL holder pack

15mL holder pack

This option allows the use of up to 6 x 15mL tubes in the Precellys Evolution. It contains one tube holder and one blocking plate.
Cat. No.: S000810-PEVO0-A

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7mL rack Specific rack

7mL rack Specific rack

This option is used to handle 12 x 7mL tubes at once on the bench before or after use on the Precellys Evolution.
Cat. No.: S000748-PR480-A.0



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Centrifuge adaptor for 7mL tubes

Centrifuge adaptor for 7mL tubes

Specific centrifuge tube adaptor for 7mL Precellys tubes. Fits in the 50mL falcon position of centrifuges.
Cat. No.: S000749-PR480-A.0



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96WP Holder pack (V2)

96WP Holder pack (V2)

This optional tube holder allows the use of up to 96 x 0.3mL tubes (12 stripes of 8 tubes) in the Precellys Evolution. It contains one tube holder and one blocking plate.
Cat. No.: P002276-PEVO0-A


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Frequently Asked Question

  • What are the volumes of the tubes compatible with your instruments?
  • Is it possible to create my own lysis matrix?
  • What are the optimal parameters for my sample (beads, speed and tube volume)?
  • How can I prevent heat generation and keep a constant temperature of 4°C (+39°F)?
  • Read the answers and see the other questions

Precellys® Evolution, a versatile tissue homogenizer

The technology behind the Precellys® Evolution tissue homogenizer from Bertin Instruments is based on over 15 years of expertise in sample preparation. It can be used to homogenize any biological sample, whether animal, human or plant, and irrespective of whether the tissue is hard or soft. Based on the multidirectional movement of the beads in the tubes, 3D bead-beating homogenization is the most efficient and reproducible method in comparison of classical ones (mortar & pestle, sonication, blenders, high pressure homogenizers). The speed can be set to up to 10,000 rotations per minute.
Precellys® Evolution allows you to use six different tube volumes (from 0.3 to 15 ml) and prepare between 1 and 96 tubes at the same time.

In areas as varied as pharmacology, medical research, forensic medicine, the environment, microbiology or agronomy, Precellys® Evolution saves you precious time in your routine and R&D projects requiring tissue homogenization or cell disruption. This preliminary processing is crucial for proteins, drugs, metabolites, RNA or DNA extraction.

It takes just a few dozen seconds to prepare your samples, even with the hardest tissue such as teeth, bones or hair. In record time, your samples are ready for analysis, whether you use PCR, Western Blot, mass spectrometry, high-performance liquid chromatography (HPLC), or next generation sequencing (NGS).

Safe sample preparation with the Precellys® Evolution tissue homogenizer

Produced in France and suitable for use in laboratories with microbiology safety level 3, Precellys® Evolution is a robust tissue homogenizer. The patented vacuum locking system allows you to easily lock and secure the tubes before homogenization.
Protect your heat-sensitive samples during homogenization with the Cryolys® Evolution cooling unit, compatible with the Precellys® Evolution homogenizer. The efficiency, versatility and safe use of the Precellys® Evolution tissue homogenizer make it the most reliable on the market.

Reasons to choose Precellys Evolution homogenizer

Expert advice


François d'Hubert

Application and Product specialist

""Check your sample's weight in order to choose the right volume of your lysing kit""

François d'Hubert

Application and Product specialist

"" Are you working with Proteins or RNA? Regulate the heat with the Cryolys cooling module which prevent heat degradation of the molecules""

François d'Hubert

Application and Product specialist

""With its tube holder easily changeable, Precellys Evolution is the perfect instruments to be shared, in a lab with different type of samples while looking for the best grinding protocols for each""


Application area: Analyze proteins in cell culture

"We are very happy with the equipment, we lyse cells, we lyse microbes, both to extract proteins and DNA to perform western blot, or sequencing. The lysis is very fast, and either protein or DNA is extracted with high quality. The results are reproducible."

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Paolo Guerra

Instituto Nacional de ICencias Médicas y Nutrición Salvador Zubirán

Rating: 5.0
Application Area: Tissue sample processing for metabolism studies

"Our lab purchased this homogenizer for metabolite extraction from animal tissue. We have been using it for a couple of years with no issue. It's a very powerful device that was able to crush any tissue sample that I have tried so far. It has a great deal of customization option to accommodate any type of sample as well."

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D. Mc Laughlin

NYU School of Medicine


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