Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers - Bertin Instruments

    Scientific publications

    Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

    Victor Certal,† Frank Halley,*,† Angela Virone-Oddos,† Cécile Delorme,† Andreas Karlsson,‡ Alexey Rak,‡Fabienne Thompson,† Bruno Filoche-Rommé,† Youssef El-Ahmad,† Jean-Christophe Carry,†Pierre-Yves Abecassis,§ Pascale Lejeune,† Loic Vincent,† Hélène Bonnevaux,† Jean-Paul Nicolas,†Thomas Bertrand,‡ Jean-Pierre Marquette,‡ Nadine Michot,∥ Tsiala Benard,⊥ Peter Below,#Isabelle Vade,† Fabienne Chatreaux,† Gilles Lebourg,† Fabienne Pilorge,† Odile Angouillant-Boniface,†Audrey Louboutin,† Christoph Lengauer,† and Laurent Schio
    Sources: †Oncology Drug Discovery, ‡Structural Biology and Molecular Modeling, §Drug Safety, ∥Protein Production, ⊥Formulation, #Parallel Synthesis, Sanofi Research & Development, 13 quai Jules Guesde, 94403 Vitry-sur-Seine, France
    Journal of Medicinal Chemistrydx.doi.org/10.1021/jm300241b | J. Med. Chem. 2012, 55, 4788−4805

    Sample name

    Animal tissues (tumors mice)

    Kits

    CK28_2mL

    ANY QUESTIONS? CONTACT AN EXPERT

    Please fill in this form if you wish to contact our sales team or receive further information.

    My Account
    Forgot password ?

    Add a question !

    Add a question