Discovery of Novel Orally Bioavailable Oxaborole 6-carboxamides that Demonstrate Cure in a Murine Model of Late Stage Central Nervous System African Trypanosomiasis - Bertin Instruments

    Scientific publications

    Discovery of Novel Orally Bioavailable Oxaborole 6-carboxamides that Demonstrate Cure in a Murine Model of Late Stage Central Nervous System African Trypanosomiasis

    Bakela Nare,*1 Stephen Wring,*1 Cyrus Bacchi,2 Beth Beaudet,1 Tana Bowling,1 Reto Brun4,5, Daitao Chen,1 Charles Ding,3 Yvonne Freund,3 Eric Gaukel,1 Ali Hussain2 , Kurt Jarnagin,3 Matthew Jenks,1 Marcel Kaiser4,5, Luke Mercer1, Elena Mejia2, Andy Noe1, Matt Orr1, Robin Parham1, Jacob Plattner3, Ryan Randolph1, Donna Rattendi2 , Cindy Rewerts,1 Jessica Sligar,1 Nigel Yarlett2, Robert Don,6 and Robert Jacobs1
    Sources: 1SCYNEXIS Inc., Research Triangle Park, NC, 2 Haskins Laboratory, Pace University, New York, NY, 3Anacor Pharmaceuticals Inc., Palo Alto, CA, 4 Swiss Tropical Institute and Public Health , Basel, Switzerland, 5University of Basel, Switzerland, 6 Drugs for Neglected Disease Initiative, Geneva, Switzerland.
    Antimicrob. Agents Chemother. doi:10.1128/AAC.00498-10American Society for Microbiology,

    Sample name

    Animal tissue (Mice brain)

    Kits

    CK14_2mL

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