Drug extraction from brain, muscle rat tissues - Bertin Instruments

Pharmacology

Drug extraction from brain, muscle rat tissues

Sources: PharmOptima, Portage MI, USA

Context

PharmOptima focuses on in vivo and in vitro DM&PK and Discovery Services, providing IND & NDAenabling research protocols. High quality DM&PK and Ocular PK research are a part of the laboratory’s daily activities. PharmOptima lab currently uses Precellys to homogenize a variety of animal tissues. In this study, Minilys has been compared with Precellys to homogenize brain and rat muscle.

Results

The analyte levels by samples are equivalent. No difference involving the both homogenizers is detectable (See Figure 1).

 

Figure 1: LC-MS/MS analysis from Precellys and Minilys sample.

Figure 1: LC-MS/MS analysis from Precellys andMinilys sample.

 

Muscle tissues in CKmix kit 2mL vial

Muscle tissues in CKmix kit 2mL vial

 

Minilys processing

Minilys processing

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