Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance - Bertin Instruments

Scientific publications

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

Sheila R.Costford (1, 2, 6, 7), Bram Brouwers (3,7), Meghan E.Hopf (1), Lauren M.Sparks (1, 3), Mauro Dispagna (1), Ana P.Gomes (4), Heather H.Cornnell (3), Chris Petucci (1), Peter Phelan (1), Hui Xie (2, 3), FanchaoYi (3), Glenn A.Walter (5), Timothy F.Osborne (1), David A.Sinclair (4), Randall L.Mynatt (2), Julio E.Ayala (1), Stephen J.Gardell (1), Steven R.Smith (1, 2, 3)
Sources: (1) Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA — (2) Pennington Biomedical Research Center, Baton Rouge, LA, USA — (3) Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA — (4) Harvard Medical School, Boston, MA, USA — (5) University of Florida, Gainesville, FL, USA

Abstract

Objective

Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance performance, and mitochondrial gene expression, and would be rescued from metabolic abnormalities that developed with high fat diet (HFD) feeding.

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