Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1 a and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia - Bertin Instruments

    Scientific publications

    Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1 a and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia

    Jun Yang,1 Afshan Ahmed,2 Evon Poon,2 Nina Perusinghe,1 Alexis de Haven Brandon,3 Gary Box,3Melanie Valenti,3 Suzanne Eccles,3 Kasper Rouschop,4 Brad Wouters,5 and Margaret Ashcroft1,2
    Sources: 1 Cell Growth Regulation and Angiogenesis Team, Cancer research, UK Centre for Cancer Therapeutics, the Institute of Cancer research,, 15 Cotswold Rd., SaHon, Surrey SM2 5NG, United Kingdom2 Hypoxia Signalling and Angiogenesis Laboratory, Centre for Cell Signalling and Molecular Genetics, Department of Metabolism and Experimental Therapeutics, Division of Medicine, Univerisity College London, Rayne Building, 5 University Street, London WC1E 6JJ, United Kingdom3 Tumor Biology and Metastasis Team, Cancer research, UK Centre for Cancer Therapeutics, the Institute of Cancer research,, 15 Cotswold Rd., Sutton, Surrey SM2 5NG, United Kingdom34 Maastricht Radiation Oncology (Maastro), University of Maastricht, 6200 Maastricht, The Netherlands5 Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada M5G OA3
    MOLECULAR AND CELLULAR BIOLOGY, Apr. 2009, p. 2243-2253 Vol. 29, No. 80270-7306/09/$08.00 0 doi:10.1128/MCB.00959-08

    Sample name

    Animal tissues (tumors cells mice)

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