Systematic Evaluation of Extraction Methods for Multiplatform- Based Metabotyping: Application to the Fasciola hepatica Metabolome - Bertin Instruments
Systematic Evaluation of Extraction Methods for Multiplatform- Based Metabotyping: Application to the Fasciola hepatica Metabolome
Jasmina Saric,† Elizabeth J. Want,† Urs Duthaler,‡ Matthew Lewis,† Jennifer Keiser,‡ John P. Shockcor,§ Gordon A. Ross,# Jeremy K. Nicholson,† Elaine Holmes,*,† and Marina F. M. Tavares*,†,∥
Sources: †Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander FlemingBuilding, South Kensington, London SW7 2AZ, United Kingdom; ‡Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerlandand University of Basel, CH-4003 Basel, Switzerland; §Pharmaceutical Business Operations, Waters Corporation, Milford, Massachussetts 01757, United States; #Agilent Technologies Life Sciences and Chemical Analysis, Lakeside, Cheadle Royal Business Park, Stockport, Cheshire, SK8 3GR, United Kingdom;∥Institute of Chemistry, University of Sao Paulo, P.O. Box 26077, 05513-970, Sao Paulo, SP, Brazil
Received: April 3, 2012Accepted: July 12, 2012pubs.acs.org/ac American Chemical Society dx.doi.org/10.1021/ac300586m | Anal. Chem.