The mTORkinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington’s disease - Bertin Instruments

    Scientific publications

    The mTORkinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington’s disease

    Jonathan H Fox1,3, Teal Connor1, Vanita Chopra1, Kate Dorsey1, Jibrin A Kama1, Dorothee Bleckmann2,Claudia Betschart2, Daniel Hoyer2, Stefan Frentzel2, Marian DiFiglia1, Paolo Paganetti2 and Steven M Hersch*1
    Sources: 1 MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Charlestown, MA, USA
    Fox et al. Molecular Neurodegeneration 2010, 5:26http://www.molecularneurodegeneration.com/content/5/1/26doi: 10.1186/1750-1326-5-26

    Sample name

    Animal tissue (muscle mice)

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