The lab mouse is the most commonly used mammalian model system for genetic research. Scientists from a wide range of biomedical fields have used the mouse because of its close genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated and analyzed. Sample preparation is a critical step before proceeding to molecular down-stream analysis. Especially for thermo-sensitive molecules such as RNA. The Cryolys® Evolution cooling unit combined with Precellys® Evolution can be used to maintain a constant low temperature of 4°C within the Precellys sample processing chamber.