Pharmacology - Bertin Instruments

    Pharmacology

    Pharmaceutical research starts with molecule leads identifications either from natural model or artificial.
    In both cases, the DMPK or animal toxicology models analysis, require to homogenize tissues.

    In preclinical dermatological research for instance, complete skin homogenization is critical to determine the amount of compound delivered into the dermis and epidermis, which helps select for the best formulation prototype. The mass spectrometry analysis is often used for such application.

    In addition to the capabilities of the Precellys to homogenize animal tissue, these instruments can also be used for micro or nano-milling of poorly water-soluble drugs to enhance bioavailability in pharmacokinetic studies. In clinical formulation development, the amount of active pharmaceutical ingredient (API) is often limited, and co-micromilling or nano-milling with various pharmaceutical excipients has been tested on the Precellys to increase solubility and dissolution rate of poorly water-soluble drug compounds.

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