Application note on Forensic Applications - Bertin Instruments

Application note on Forensic Applications

Sources: National Institute of Criminalistics and Criminology, Brussels (Belgium), Insituto de Criminalistica (Brazil), Department of Forensics Science (USA), Drug Analysis Laboratory for the Supreme Prosecutors’ Office (Republic of Korea), Forensics Toxicology Service in the Institute of Legal Medicine (Spain), Federal Public Service Justice, Section of Forensic Chemistry, Department of Forensic Medicine, University of Copenhagen (Denmark). National Centre for Forensic Studies, University of Canberra, Bruce (Australia)


Forensic laboratories working with hard samples such as hair [1, 2, 8, 9, 10, 13, 14], bone [3], teeth, skin, etc. experience difficulties with DNA extraction due to the high energy needed to grind these tissues. Moreover, biological evidence is available in small quantities and the current techniques used do not provide high quality results. The Precellys homogenizers provides high speed sample disruption based on beadbeating for the extraction of DNA, proteins, and drugs [1, 2, 5, 7, 9, 10, 12, 13, 14 ] within minutes with high reproducibility and no cross-contamination.


- [2] Laloup M, et al. Detection of diazepam in urine, hair and preserved oral fluid samples with LCMS/ MS after single and repeated administration of Myolastan and Valium. Anal Bioanal Chem 2007; 388: 1545-56. - [3] Toledo DM. Precellys24 forensics practice. Curitiba 2009. Universidade Positivo, Instituto de Criminalistica do Parana. - [4] Castaing N, et al. Suicide with Cisatracurium and Thiopental: Forensics and Analytical Aspects. J Anal Toxicol 2011; 35: 376-380. - [5] Castaing N, et al. Postmortem redistribution of two antipsychotic drugs, Haloperidol and Thioridazine, in the rat. J Anal Toxicol 2006; 30: 419-425 - [6] Concheiro M, et al. Ethylglucoronide determination in urine and hair from alcohol withdrawal patients. J Anal Toxicol 2009; 33: 155-61. - [7] Gosselin M, et al. Methadone determination in puparia and its effect on the development of Lucilia sericata (Diptera, Calliphoridae). Forensics Sci Int 2011; 209: 154-159. - [8] Kim JY, et al. Rapid and simple determination of psychotropic phenylalkylamine derivatives in human hair by gas chromatography-mass spectrometry using micro-pulverized extraction. Forensics Sci Int 2010; 196: 43-50. - [9] Lendoiro E, et al. Target screening and confirmation of 35 licit and illicit drugs and metabolites in hair by LC-MS/MS. Forensics Sci Int 2012; 217: 207-15. - [10] Nielsen MKK, et al. Pre-analytical and analytical variation of drug determination in segmented hair using ultra-performance liquid chromatography-tandem mass spectrometry. Forensics Sci Int 2014; 234: 16-21. - [11] Yu J, et al. LC-MS/MS analysis of 2-aminothiazoline-4-carboxylic acid as forensic biomarker for cyanide poisoning. World J Methodol 2012; 2: 33-41.


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