With more than several thousand publications in under two years, CRISPR-Cas9 revolutionized the science world and more particularly cellular and molecular biology. CRISPR-Cas9 technology allows genetic editing through mutation. For example, this leads to the generation of Knock-In or Knock-Out mice for animal studies [1]. Introducing mutation requires some controls to check the validity and efficiency of the mutation with classic method like PCR, sequencing [2], Western Blot, cell-based assays, and more. Precellys is then used, as the gold standard to perform sample disruption to grind tissue or cells. Complete homogenization is needed to extract high quality DNA, RNA or protein for further downstream processing. The Precellys Evolution combined with a dedicated lysing kit is the best partner to save time and improve efficiency of sample preparation protocols. Not only for CRISPR-cas9 but in every molecular and cellular study, the quality of DNA, RNA or any other molecule of interest is critical. The Precellys can efficiently homogenize any sample type while maintaining reproducibility among biological replicates and eliminating cross-contamination. This instrument is frequently used on research protocols, ensuring a fast and efficient sample disruption process. Find related articles with a combination of CRISPR-Cas9 and Precellys homogenizers: [1] Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome [2] Targeted mutagenesis in Atlantic salmon (Salmo salar L.) using the CRISPR/Cas9 system induces complete knockout individuals in the F0 generation